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Hold at each step for at least two weeks before increasing

The analysis was carried out using an Acquity UPLC HSS T3 column (1.7 m, 50 2.1 mm) with an optimised gradient programme

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544 Interventions, such as pressure offloading using therapeutic footwear and insoles, help redistribute pressure and prevent ulcer formation, while establishing multidisciplinary foot care teams involving endocrinologists, podiatrists, surgeons, and nurses reduces amputation rates and healthcare costs

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