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Surplus ROS attack DNA, inducing damage [107], and oxidize proteins, leading to protein misfolding and functional loss [108]

doi: 10.1016/j.pharmthera.2013.07.003 191 YuanXCaiCChenSChenSYuZBalkSP

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Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage

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These results indicated that Sirt1 regulated the nuclear translocation of Gli-1 and the expression levels of components of the Shh signaling pathway in N9 microglia following OGD/R injury in vitro