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SS-31s effects on muscle tissue make it particularly relevant for active patients and athletes: Improved lactate clearance: mitochondrial efficiency affects how quickly lactate accumulates during high-intensity exercise and how quickly it is cleared during recovery Reduced exercise-induced oxidative stress: the oxidative stress generated by intense exercise is substantially mitochondrial in origin

In this review we will focus on (a) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (b) importance of oxidative stress and antioxidants in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease, (c) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (d) new therapies that include antioxidant defenses restoration

Curcumin, inflammation, and chronic diseases: How are they linked

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Consistently high cortisol levels, however, can lead to fatigue, anxiety, weight changes, and trouble sleeping

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