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Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69

Bremelanotide is a synthetic peptide drug and the first of a new class: melanocortin receptor agonists

Cyclin-dependent kinase 1 (CDK1) is a crucial protein for cell cycle control and is known to be upregulated in LSCC, making it an attractive therapeutic target [49]

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