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The actual B12 remains in your system longer, but active levels gradually decline as your body utilises it

Heres a discussion on the safety profile of B-Complex Vitamin IV therapy: Safety Profile of B-Complex Vitamin IV Therapy: B-complex vitamins are water-soluble, meaning that excess amounts are usually excreted through urine

GI disease, food allergies, age, stress, and taking drugs and or medications can cause a decrease in activity of any of these, and therefore will lead to B12 deficiency