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Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)

Clinical studies have shown that both medications can result in significant weight loss for individuals with type 2 diabetes

Consult a healthcare provider before starting any supplement or protocol

2020;8:e1443

Exploring the bioactive landscape: peptides and non-peptides from the human microbiota