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Nrf2 acts as a vital in vivo antioxidant protector, with research indicating that Nrf2 pathway activation safeguards retinal tissue in patients with diabetes (359, 360)

Ventura MT, Polimeno L, Amoruso AC, Gatti F, Annoscia E, Marinaro M, Di Leo E, Matino MG, Buquicchio R, Bonini S, Tursi A, Francavilla A

Cell 117(3):399412 Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

Common adverse reactions included nausea, diarrhea, and vomiting

[25] showed that hyperbaric oxygen therapy can significantly improve sperm motility in patients diagnosed with oligospermia

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