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Tirzepatide may reduce oral contraceptive effectiveness during dose escalation, so alternative or backup contraception methods should be considered

When cut in a protective way, the brain forms neuroprotective fragments instead of plaques

ROS dysregulation in cardiovascular diseases ROS dysregulation represents a central node in cardiovascular diseases progression [314], involving endothelial dysfunction [315], cardiomyocyte injury [316], mitochondrial [317] and endoplasmic reticulum stress [318], vascular remodeling [319], and atherosclerosis [320]

In this context of rapid global aging, elucidating the molecular mechanisms underlying skin aging and developing effective intervention strategies remain urgent challenges across dermatology, geriatric medicine, and public health