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Mutations in important arginine residues located on the p53-DNA-binding surface facilitate the loss of transcriptional activity and sequence-specific DNA binding

Its a classic ball-and-socket, but the socket is incredibly shallow

doi: 10.1056/NEJMe2202547 123 IottiS.WolfF.MazurA.MaierJ

Current evidence indicates that l-carnitine may lower blood pressure, improve insulin response, and reduce insulin resistance

A: Over 50 years of published research documenting collagen synthesis stimulation, wound healing promotion, anti-inflammatory effects, and regulation of tissue remodeling and anti-oxidant defense genes

Could this regulation by acetylcarnitine occur by changing the acetylation status of histone and non-histone nuclear proteins