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Here is how the 2025 changes are most likely to affect those looking to use these weight loss medications

Safety and effectiveness in people over 65 or under 18 hasnt been established yet

Researchers who understand lyophilized versus liquid peptide quality markers are better positioned to evaluate test results meaningfully

For someone primarily focused on weight loss without specific cardiovascular concerns, tirzepatide's superior efficacy data may be more relevant

Compounded semaglutide is generally recommended for patients with specific needs not met by commercially available products

Tirzepatide data from SURMOUNT and SURPASS trials demonstrate superior weight loss and glycemic control compared to existing GLP-1 RAs