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To implement the encoding of the new data elements we are finalizing in this final rule with comment period, we now estimate that it will take a Business Operations Specialist (BLS 13-1000), on average, 8 hours (at a cost of $87.52 per hour) to develop and update the necessary processes and procedures and develop the requirements to implement the new data elements and a General and Operations Managers (BLS 11-1021), on average, 2 hours (at a cost of $128.00 per hour) to review the updates, and a Chief Executive (BLS 11-1011) 2 hours (at a cost of $252.82) to review and attest to the accuracy and completeness of the data in the MRF

The reasons why vary, but typically this is because a highly inbred strain is used in preliminary studies or because the mice are not housed properly (control group shows depressed lifespan)

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In these granulomas, lymphocytes were clustered into multiple, small foci, particularly in the untreated (Figures 10AC) and L-GSH-alone (Figures 10DF) or RIF (Figures 10GI) alone treated mice lungs