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In addition to the traditional CAR design with a CD28 transmembrane domain (TMD), we introduced a de novo TMD design following a programmable membrane protein (proMP) strategy 16

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90110 1 : -24 (, 0.25 ) 3 : -610 ( ) 6 : -1015 ( ) 12+ : -1420 ( ) STEP-1 + (PubMed 2024) 86.4% 5% 69.1% 10% 50.5% 15% 2+ (STEP-5) STEP-1 (NEJM, 2021) : 1 961 , 68

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