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While effective for blood sugar control, could these treatments pose hidden risks to muscle health, particularly in older or already at-risk individuals

Follow-up studies and disease registries will be essential to determine whether such benefits translate into lower CKD progression rates or cancer incidence in MASH cohorts

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Importantly, neither medication has been linked to increased cardiovascular risk in trials to date

These pleiotropic actions underscore the potential of PCs as promising therapeutics for DR and warrant further investigation in both preclinical and clinical settings