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Steitz et al 6 reported that VSMCs undergo a phenotypic transition into osteoblast-like cells in response to mineralization, evidenced by an increase in the expression of ALP, osteocalcin, Cbfa1 and osteopontin

However, it did not have a significant effect on chromosomal fragility that was already present

Vezzani A, French J, Bartfai T, Baram TZ

This extended stay can lead to an increased risk of constipation as more water is absorbed from the waste, hardening the stool further