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This may have some potential benefits for managing type 2 diabetes and weight , but berberine isn't easily absorbed in the intestines, which limits how effective it can be
The average patient with T1D experiences two episodes of symptomatic hypoglycemia a week ( In RCTs comparing GLP-1RA and placebo, insulin doses were reduced before GLP-1RA initiation to avoid hypoglycemia, and close monitoring and insulin adjustments were done periodically
But if you consistently exercise at the same time you inject, be aware that the absorption spike may be faster than expected
On the other hand the GLP1R in both cardiomyocytes and sinoatrial node cells can activate cyclic AMP (cAMP)-dependent signaling pathways
Lotte Bjerre Knudsen (25:05): I wouldn't be able to say that, and I don't think there are any, well, it's hard to keep up that the entire literature on GLP-1 these days, but I don't think anyone has actually shown that there is a separation because it's super hard to separate when things are occurring at the same time
Plus there are indications it could even treat addiction
