Common side effects include: Injection site reactions mild pain, redness, swelling, or bruising at the injection site, typically resolving within a few days Headache usually transient and manageable with standard analgesia Nausea or dizziness particularly in the initial treatment phase Skin reactions including itching, mild rash, or acneiform eruptions Temporary urine discolouration red or orange urine is harmless and expected Diarrhoea or flushing usually mild and self-limiting In patients with severe megaloblastic anaemia, low potassium levels (hypokalaemia) may occur during initial intensive treatment, but this is uncommon in routine maintenance therapy
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Once it reaches the small intestine, the liposome is absorbed into the bloodstream
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Glutathione steps in during Phase II, known as the conjugation phase, to neutralize these highly reactive intermediates before they can cause systemic tissue damage
Competing interests: All authors have read and approved of the contents of the manuscript and none of the authors have competing financial interests
