The non-randomized trial by Pettegrew et al 12 assessed with ROBINS-I, showed a critical risk of bias from confounding and serious risk from participant selection, although other domains were low risk
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with the limitation of an observational approach) suggested that these favorable results may be considered as a class effect shared by all SGLT-2 inhibitors (including dapagliflozin) and be extrapolated to a larger population of patients with type 2 diabetes mellitus in primary prevention
Hu Y, Huang J, Li Y, Jiang L, Ouyang Y, Li Y, et al