Instead, the change tends to feel like the heavy, dragging feeling slowly lifting
While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables
For most people taking B12 at standard supplemental doses as part of a well-formulated multivitamin, this isn't a concern
Monitor for Results and Side Effects: Track changes in weight, body measurements, energy levels, and any adverse reactions
The results showed statistically significant but clinically modest weight loss (2kg average advantage over placebo at the 1mg oral dose over 23 weeks)
Key findings include a 70% increase in skin thickness after 12 days of topical application, wrinkle volume reduction of 55.8% and depth reduction of 32.8% in clinical studies, and accelerated wound healing across multiple models (Pickart et al., 2018)