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Absorption: Bioavailability is the most important factor

JCI Insight (2020) 4

Formaldehyde formed was reported as a carcinogenic substance

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5 Renal targeting challenges and novel approaches The complexity of the kidney, including diverse cell types and structural components, complicates efforts to protect and restore renal function, while challenges in developing effective drug delivery systems for renal diseases are widely acknowledged [73]

As to a connection with ER stress, many xenobiotics have been shown to influence the UPR signalling route, with either pro-survival or pro-death features - unsurprising given that resident CYP straddle ER membranes (84)