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Efficacy of L-arginine and Pycnogenol in the treatment of male erectile dysfunction: a systematic review and meta-analysis (2023)

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Tirzepatide tends to be the better fit when: the goal is more significant weight loss (15 percent or more of body weight), the patient has type 2 diabetes with A1C above target on prior therapies, prior single-pathway GLP-1 use produced limited results, or the patient tolerated GLP-1s reasonably well and wants a stronger next step

Methods We conducted a single-center observational cohort study that included adult patients with IBD who were started on GLP-1-based therapy (semaglutide or tirzepatide) for weight loss from January 2021 to April 2024