Mechanistically, the common thread appears to be dampening drug-evoked dopamine signaling in the nucleus accumbens and engaging GLP-1 anti-craving circuits involving the VTA, nucleus accumbens, lateral septum, laterodorsal tegmentum, and nucleus tractus solitarius
The compound received marketing approval in China in June 2025 under the brand name Xinermei, making it the first domestically approved dual GLP-1/glucagon agonist anywhere in the world
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The results of regulated ACSL4 expression were tested by immunoblotting