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If cost constraints require shared vials, use individual sterile syringes for each draw, never insert a used needle back into the vial, and maintain detailed logs of draw dates and volumes to track remaining dose accuracy

Abstract Osteoarthritis (OA) is one of the leading causes of disability worldwide, characterized by a complex pathological process involving cartilage degradation, synovial inflammation, and subchondral bone remodeling

Two Phase 3 trials for AD109 with similar design to MARIPOSA are ongoing with topline results anticipated in mid-2025

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Further, one also has to consider the benefits to patients