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Studies in which muscle IGF-I production is increased by transgenic or viral over-expression 3335 take advantage of the mismatch between the capacity of muscle to use IGF-I and its production to promote functional hypertrophy

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Phase II data showed up to 20% weight loss at 52 weeks, with a unique dual mechanism of GIP receptor antagonism and GLP-1 receptor agonism, aiming to improve weight loss durability