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In primary human skeletal muscle myoblast cultures (serum-free, 72 h), IGF-1 LR3 (10 nM) produces 4856 h sustained pAkt(Ser473) elevation (+2.22.8 over baseline), whereas equimolar native IGF-1 shows peak pAkt at 612 h and return to baseline by 2430 h due to IGFBP-3 sequestration

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Alternative therapies should be strongly considered

WHO Director-General Tedros Adhanom Ghebreyesus said the new guidance recognizes that obesity is a chronic disease that can be treated with comprehensive and lifelong care