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doi: 10.1111/anu.2013.19.issue-6 75 ZhangH.YangW.LiY.HuL.DaiY.ChenJ.et al

445,446 A reduction of NAD + levels in cells is observed in many tissues with obesity, like the skeletal muscles, hypothalamus, liver and adipose tissue

Your metabolic rate also adapts to the lower weight you achieved during treatment

However, the balance is very narrow and must be better defined for therapeutical approaches, since decreasing NAD may lead to a decrease in pluripotency, aging, neurodegeneration, and immune response, while an excessive increase may contribute to cancer

This gives providers the clinical flexibility to increase, hold, or reduce dose based on your actual week-to-week response

Low-calorie fatigue results from reduced food intake, calorie deficit, and low energy levels