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At 48 weeks, 93% of participants on the 12 mg dose achieved normal liver fat levels (below 5%), with a mean relative reduction of 86% in hepatic fat content
In both cases, the spheroids were engineered with the goal of serving as building blocks for cardiac tissue patches intended for future grafting into damaged native myocardium and aid in the treatment of heart failure
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Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models
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