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Ipamorelin dosing at 200-300 mcg comes from Bowers' dose-response work in the 1990s and subsequent phase-I/II trials showing reliable GH pulses at that range

Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)

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Researchers also distinguish reduced glutathione (GSH) from the disulfide GSSG, since it is the GSSG/2GSH ratio, not total glutathione, that Schafer and Buettner (Free Radical Biology and Medicine, 2001) established as the quantitative index of the cellular redox environment