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(c) Weight in grams shown for normal C57BL/6J mice pre- and post-vehicle control or MT-II treatment for 14 days (vehicle, n = 7

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Additionally, the high levels of LA, low pH, hypoxia, and reactive oxygen species (ROS) prevalent in the TME can impair T cells and natural killer cells while polarizing tumor-associated macrophages into a pro-tumoral M2-like phenotype, collectively facilitating immune evasion [20]

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The author BS declared that they were an editorial board member of Frontiers at the time of submission