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Nearly one-third of users said they wish they had known how common side effects would be before starting GLP-1s

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Interestingly, neither exendin-4 or GLP-1 stimulated amylase release from isolated acini of guinea pig or rat pancreas but both potentiated secretion induced by CCK (66, 94, 124)

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however, it piqued significant public and commercial interest in 2021 when the STEP-1 trial demonstrated up to 14% placebo-adjusted weight loss, leading to its approval as a weight loss drug, Wegovy

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