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Proteostasis as an integrated multilayer network: a conceptual framework Proteostasis is sustained by a hierarchically organized and tightly interconnected network of processes that collectively determine whether proteins remain functional, are repaired or are eliminated

Variants in GLP1R, GIPR, FTO, MC4R, and TCF7L2 are associated with measurably different response patterns to GLP-1 and GIP/GLP-1 therapy

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