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A 2022 meta-analysis in Antioxidants found that NAC supplementation (a glutathione precursor) modestly improved HOMA-IR (insulin resistance) in adults with metabolic syndrome, though the effect size was small (Cohen's d = 0.31)

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doi: 10.1016/j.lfs.2025.123507 19 YingZMingJJin-YuSChenCHuiSWeiSet al