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GLP-1R agonists mimic the physiological effects of endogenous GLP-1 while exhibiting improved stability and prolonged activity compared to the native peptide
The tradeoff is doubling the number of injection events per week
Cardiovasc Res
A newer GLP-1 receptor agonist, tirzepatide, demonstrates weight loss as high as 20% change in body weight compared with 3% in the placebo group in a RCT
The therapeutic potential of gut hormone peptide YY3-36 in the treatment of obesity
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