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Nasal symptoms alone are rarely a reason to discontinue medication

During gavage mice were under light anesthesia to limit discomfort (3% isoflurane at a 1.5 L/min O 2 flow rate for ~1 min)

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HFpEF exhibits more complexity and has more associated-comorbidities including hypertension compared to HFrEF, and systemic inflammation and its-induced metabolic injury are closely associated with the pathogenesis of HFpEF

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