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This, therefore, answers the next question

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We selected cell lines originating from different organs known to be targets of metal poisoning, namely, Huh7 (liver, hepatocellular carcinoma), 1321N1 (brain, astrocytoma), U937 (blood, histiocytic lymphoma), HCT116 (colon, carcinoma), and the hTERT-immortalized cell line RPE1 (eye, retinal pigment epithelial cells)

The phosphodiesterase 4 inhibitor roflumilast augments the Th17-promoting capability of dendritic cells by enhancing IL-23 production, and impairs their T cell stimulatory activity due to elevated IL-10

William Crook, Dr

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