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In mice bred to be deficient in mast cells (kit mutation), fibrosis and a-fib did not develop.[ref] Related article : Atrial fibrillation genes Mast cells are also implicated in the narrowing of the arteries due to atherosclerosis and play a role in stress-induced coronary artery disease

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That design is common in trials comparing agents with different administration requirements, but it can influence reported outcomes, particularly subjective ones such as appetite and gastrointestinal symptoms

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Around 10% of the 66 million Medicare beneficiaries are expected to be eligible for the drugs starting next year with new, expanded access