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Issues raised in academic and consumer reviews include irritation in cosmetic-formulation use, very wide variation in product quality across the unregulated marketplace, formulation-stability problems, ingredient-interaction concerns, and a thin clinical-trial evidence base relative to the strength of consumer marketing claims

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Both v6 and v8 integrins facilitate TGF activation by interacting with the RGD sequence present in the latent, inactive LAP (latency-associated peptide)-TGF complex