Oxidative damage and antioxidant defense in ferroptosis
Although the precise significance of the differences in the pattern of CAT and GPx activity and their respective mRNA expressions in SHR and WKY rats in this study remains unclear, it is nevertheless interesting to note that the differences in renal mRNA expression and activities of CAT and, to some extent, that of GPx, between SHR and WKY rats reported in this study, became apparent before the actual rise in blood pressure in SHR
Erastin induces the expression changes in ferroptosis markers and inhibits melanin synthesis in melanocytes, which can be attenuated by N-acetyl-L-cysteine (NAC) pretreatment or post-treatment in vitro
Note: The below protocol is a sample protocol
Heerspink HJ, Desai M, Jardine M, Balis D, Meininger G, Perkovic V
Warning: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product