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In most cases, no its temporary
Antioxidant Depletion: In an ironnitrilotriacetic acid rat model of hemochromatosis, renal samples showed increases in reactive intermediates, accompanied by decreased availability of systems that protect against oxidation by iron, such as vitamin E levels, the glutathione system, thiol-specific antioxidants, and superoxide dismutase
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Any excess or unwanted vitamin B-12 is excreted in the urine
Dosing changes often depend on lab results, changes in body composition, or specific treatment targets
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