Although the body inherently possesses an antioxidant defense system to protect your body against damage from free radicals, a buildup of free radicals can contribute to premature aging and enhance the progression of chronic diseases like heart disease, cancer, type 2 diabetes, and Alzheimers 5, 6
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The hepatotoxicity of APAP rests predominantly with the highly toxic and reactive compound NAPQI, which forms covalent bonds with sulfhydryl groups on cysteine and lysine molecules within the mitochondria of hepatocytes and which spontaneously reacts with GSH and binds to hepatic proteins
Effects of tetrahydrocannabinol on glucose uptake in the rat brain
Further research into the role of selenium and GSH-Px is required (Beasley et al., 1991)