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Safety concerns with IV glutathione for skin lightening: Side effects including skin rashes, abdominal pain, thyroid dysfunction, liver dysfunction, kidney dysfunction, and possible kidney failure have been reported with intravenous glutathione injections [60]

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But in the cytosol, even during oxidative stress, the ratio of GSH/GSSG remains very high, which makes that exchange reaction unfavorable

10.1104/pp.104.058719 Plant Physiol

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