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Crucially, this happens without IGF-1 stimulation

Persistent stimulation leads to receptor desensitization

In this study, HU was found to improve renal function by reducing serum creatinine and blood urea nitrogen in diabetic mice

After absorption, the substance undergoes conjugation by liver enzymes such as UDP-glucuronosyltransferases (UGTs) and sulphotransferases (SULTs), forming inactive metabolites that further reduce its plasma concentration and limit its distribution to target tissues [53]

Compound muscle action potential (CMAP) is a representation of functional motor axons and muscle fibres