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- Evidence: Meta-analysis: 91 placebo-controlled trials, 107,910 patients Retrospective cohort study: 2.2M users via FDA Sentinel System No signal for SI/B, anxiety, depression, irritability, or psychosis - Action: FDA requesting removal of SI/B warning from Wegovy, Saxenda, and Zepbound labeling

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Science has associated L-carnitine supplementation with gastric distress in high doses