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[7] But here is the critical distinction I want you to sit with: These drugs are pharmacologically suppressing appetite

In a major clinical trial called STEP 8, researchers compared the two medications directly

However, it was not possible to establish whether these histological effects were solely determined by reductions in body weight

2014;166C(3):32732

However, the substantial weight loss they facilitate does result in some loss of lean body mass, as occurs with any significant weight reduction

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