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1 Introduction In the early 2000s, studies linked metabolic syndrome as an assemblage of metabolic risk factors driving the development of cardiovascular disease (CVD) and the introduction of the term Cardiometabolic syndrome (CM) ( Figure 1 Traditional inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) have been widely used for risk assessment

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