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Br J Pharmacol 179:625641 Koob GF, Volkow ND (2010) Neurocircuitry of addiction
This dual mechanism means tirzepatide engages pathways that were not being stimulated by semaglutide, providing a form of receptor novelty
Weight loss injections typically refer to GLP-1 receptor agonists (such as semaglutide, liraglutide, or dulaglutide) or the newer dual GIP/GLP-1 receptor agonist tirzepatide
doi:10.1038/s41572-021-00265-2 28
Participants lost an average of 17.1% body weight at 48 weeks
However, as of 2026, there is no scientific evidence, specifically no published clinical trials, that supports the safety or efficacy of combining these two investigational peptides
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