As discussed in those sections, in light of these comments, we are finalizing these proposals with modification
Obese Zucker rats treated with AOD-9604 at 500 mcg/kg/day for 19 days showed a statistically significant reduction in body fat compared to vehicle-treated controls
Singly-housed rodents may have increased adiposity 101 and, moreover, singly-housed mice in standard caging can engage in coprophagy of their own feces that may impact their cecal microbiome 102
We screen for G6PD deficiency, kidney issues, and other contraindications before treatment
Physiological Genomics, 1 (2), 5162
Impaired digestion results in the start or worsening of gastrointestinal symptoms such as bloating, constipation, and/or diarrhea