Ortiz-Pujols isnt surprised to see semaglutide had a positive effect on kidney function
They also appear able to enhance microvascular (!) blood flows in the muscle tissue, reduce muscle-produced inflammation, and enhance glucose and lipid metabolism in the muscles
pathogenic variants in leptin ( LEP ), leptin receptor ( LEPR ), POMC , prohormone convertase 1 ( PCSK1 ), melanocortin 3 and 4 receptors ( MC3R and MC4R ), and SH2B1 all lead to dysregulated energy homeostasis and hyperphagia secondary to defective hypothalamic signaling [33, 34]
This combination is contraindicated in patients with known allergies to any of the individual vitamins (Cyanocobalamin / Vitamin B12, Folic Acid, Niacinamide, Vitamin C / Ascorbic Acid)
Damage at that level first shows up in egg and sperm quality, then carries over into embryonic development after fertilisation
Its crucial to consult a healthcare provider to discuss medical history and potential risks before starting the treatment