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It skips the liver's first-pass metabolism [8]

Once GH enters circulation, the liver converts much of it into insulin-like growth factor 1 (IGF-1), which is the downstream mediator responsible for most of GH's tissue-level effects lean mass preservation, lipolysis, cellular repair, and collagen synthesis among them

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A conditioned-taste aversion (CTA) experiment in male chow-fed Wistar rats affirmed a potent weight loss in response to GLP-1, semaglutide and GLP-1MK-801 compared with MK-801 and vehicle treatment

doi: 10.1038/s41586-021-04059-0, 38 GriazevaE

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