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10.1523/JNEUROSCI.1050-20.2020 J Neurosci

According to FDA prescribing information, tirzepatide should be discontinued at least one month before a planned pregnancy due to its long half-life and the lack of adequate data on fetal effects

Abbreviations ACC: Acetyl-CoA carboxylase AMPK: AMP-activated protein kinase ATGL: Adipose triacylglycerol lipase BAT: Brown adipose tissue CPT1: Carnitine palmitoyltransferase 1 FBG: Fasting blood glucose GLP-1: Glucagon-like peptide-1 GLP-1R: GLP-1 receptor H&E: Haematoxylin and eosin HFD: High-fat diet HSL: Hormone-sensitive lipase IHC: Immunohistochemical ITT: Insulin tolerance test MEF: Mouse embryonic fibroblast PGC-1: Peroxisome proliferator-activated receptor coactivator-1 mtDNA: Mitochondrial DNA PPAR: Peroxisome proliferation activated receptor RNAi: RNA interference sh: Short hairpin SIRT1: Sirtuin 1 TG: Triacylglycerol UCP-1: Uncoupling protein-1 WAT: White adipose tissue References Twig G, Afek A, Derazne E et al (2014) Diabetes risk among overweight and obese metabolically healthy young adults

An update on immune-based alpha-synuclein trials in Parkinsons disease

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Seeley et al., 2000