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Semaglutide is not weight-based Unlike some medications that are dosed by body weight (X mg per kg), semaglutide follows a fixed-dose escalation schedule

Neither drug showed serious safety concerns in studies

In kidney disease, the clinician and the patient have to think about tolerability, nutrition, fluid status, medications, and progression risk at the same time

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Following a review completed in 2024, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) concluded that available evidence did not support a causal link between GLP-1 receptor agonists and suicidal ideation or self-harm, a conclusion also reflected in MHRA communications that year

Affecting brain signals linked to hunger and appetite